SureSeq NGS products for hematological cancer and solid tumors
SureSeq™ NGS panels have been designed in collaboration with recognised cancer experts to detect key aberrations implicated in a wide range of hematological and solid tumor cancers. More so, you can modify specific panels to what’s relevant to your research with SureSeq myPanel™, our regularly updated, expert-curated library of pre-optimized cancer content. Simply mix and match the gene, exonic or intronic content you need to create an NGS cancer panel that meets your exact requirements.
Our unique panel design coupled with hybridization-based enrichment offers unparalleled coverage completeness and uniformity, allowing accurate detection of low-frequency SNVs and indels, as well as structural aberrations such as ITDs, PTDs, CNVs, LOH and translocations. Combined with our various SureSeq LPK products, SureSeq alleviates the burden of running multiple assays and streamlines your research, delivering comprehensive results using a single NGS workflow.
All SureSeq panels come with Interpret, our powerful and easy-to-use NGS analysis solution providing effortless translation of all your NGS data into meaningful results.
Learn more about our custom NGS panel service
Developed in partnership with myeloid cancer experts to the latest WHO guidance, the panel can identify novel fusion partners — providing more comprehensive and informative analyses than possible using PCR-driven methods. The figure (above) shows the consistent and confident detection of MECOM overexpression in [A] serial dilutions of HNT-34 cell line as well as [B] research and commercial samples, including positive and negative controls.
View ProductMyeloid malignancies are a heterogeneous group of diseases, associated with a wide range of variants ranging from mutations to structural variations. The panel accurately detects SNVs and indels in genes such as CEBPA, JAK2, CALR and MPL, as well as structural variants including FLT3-ITDs and KMT2A-PTDs, and is able to detect low-frequency SNVs and indels with confidence. The figure (above) shows a PTD detection spanning exons 2-8 of the KMT2A gene.
View ProductDesigned with input from recognized cancer experts to detect key variants in 70 genes implicated in a wide range of myeloid disorders, including AML, MPNs and MDS. The panel accurately detects SNVs and indels in genes such as CEBPA, JAK2, CALR and MPL, as well as structural variants including FLT3-ITDs and KMT2A-PTDs. The figure (above) shows FLT3-ITDs of various sizes and even regions containing multiple ITDs can be confidently detected. ITD sizes are [A] 174 bp, [B] 225 bp, [C] 195 bp with additional 6 bp, [D] 120 bp and [E] 168 bp with additional 69 bp.
View ProductDesigned in collaboration with recognized cancer experts to detect 13 key genes and 5 chromosomal regions implicated in CLL progression. The figure (above) compares SureSeq CLL + CNV Panel data with array data for a 42.7Mb deletion of 11q covering ATM (top) and a 0.6Mb biallelic loss called within a larger ~1Mb single allele deletion in the region covering DLEU2/DLEU1/DLEU7 on chromosome 13q (bottom).
View ProductOur latest and most advanced system for capture of targeted genomic regions and generation of NGS libraries. Delivering a 40% reduction in hands-on time compared to the previous workflow, increased accuracy and error correction with the inclusion of UDIs and UMIs and reduced workflow complexity for minimal risk of human error. The figure (above) shows the workflow.
View ProductThe kit generates NGS libraries suitable for the capture of targeted genomic regions using hybridization. Delivering high performance with low duplication rates, high sequence quality and high percentage of on-target bases. The figure (above) shows how the kit delivers exceptional sequence quality scores even 150 bases into the read.
View ProductDon’t let the quality and quantity of your FFPE samples hold back your NGS discoveries. The SureSeq™ FFPE DNA Repair Mix is a mixture of enzymes that has been optimized to remove a broad range of damage that can cause artefacts in sequencing data. The figure (above) shows example traces from the Agilent® TapeStation, illustrating the improvement in pre-capture NGS library yields when using the SureSeq FFPE DNA Repair Mix.
View ProductA powerful and easy-to-use NGS analysis solution, facilitating analysis and visualization of a wide range of variants and structural aberrations. Coupled with a comprehensive and powerful filtering framework, the software delivers accurate calling of SNVs and indels, as well as structural aberrations, including ITDs, PTDs, CNVs, LOH and translocations. The figure (above) shows detection of a KMT2A-PTD spanning exons 2-8.
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