CytoCell Smith-Magenis (RAI1)/Miller-Dieker FISH Probe

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Product summary

Technology FISH
Application Cytogenetics & rare disease
Areas of interest Constitutional
Region 17p13.3
17p11.2
Label
Product Code LPU 019-A (100μl)
LPU 019-SA (50μl)
Regulatory Status Analyte specific reagent. Analytical and performance characteristics are not established.

Documentation

Ancillary products

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Chromomaps

17p13.3 (LIS1) / 17p11.2 (RAI1)

FISH chromosome map showing probes targeting regions associated with Smith-Magenis (RAI1 gene) and Miller-Dieker syndromes.

Overview

Probe specification

LIS1 (PAFAH1B1), 17p13.3, Red
RAI1, 17p11.2, Green

The Miller-Dieker (LIS1) probe is 117kb, labeled in red and covers the entire LIS1 (PAFAH1B1) gene. The Smith-Magenis (RAI1) probe is 158kb, labeled in green and covers the centromeric end of the RAI1 gene and includes the D17S258 marker. The two unique sequences act as control probes for each other and allow identification of chromosome 17.

Fluorescence in situ hybridization (FISH) microscope image of the CytoCell Smith-Magenis (RAI1)/Miller-Dieker Region probe.

What our customers say

I first came across CytoCell FISH probes in a previous lab I worked in and I was struck by the quality of the products. Since this time, I have been recommending and introducing CytoCell probes across all application areas — now they are the primary FISH probes used in our lab. They have an excellent range of products and their ready-to-use reagent format saves considerable time.