The Miller-Dieker (LIS1) probe is 117kb, labeled in red and covers the entire LIS1 (PAFAH1B1) gene. The Smith-Magenis (RAI1) probe is 158kb, labeled in green and covers the centromeric end of the RAI1 gene and includes the D17S258 marker. The two unique sequences act as control probes for each other and allow identification of chromosome 17.
I first came across CytoCell FISH probes in a previous lab I worked in and I was struck by the quality of the products. Since this time, I have been recommending and introducing CytoCell probes across all application areas — now they are the primary FISH probes used in our lab. They have an excellent range of products and their ready-to-use reagent format saves considerable time.
Elizabeth Benner
Medical Technologist, University of Arizona Health Network, USA
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